Peer-reviewed research articles

  • Balakrishnan PB, Ledezma DK, Cano-Mejia J, Andricovich J, Palmer E, Patel VA, Latham PS, Yvon ES, Villagra A, Fernandes R*, Sweeney EE*. "CD137 agonist potentiates the abscopal efficacy of nanoparticle-based photothermal therapy for melanoma," Nano Research, 2021, doi: 10.1007/s12274-021-3813-1.

    • IB-001 effectively treats melanoma that is resistant to immune checkpoint inhibition.​

  • Shukla A, Cano-Mejia J, Andricovich J, Burga RA, Sweeney EE, Fernandes R. "An Engineered Prussian Blue Nanoparticles‐Based Nanoimmunotherapy Elicits Robust and Persistent Immunological Memory in a TH‐MYCN Neuroblastoma Model," Advanced NanoBiomed Research, 2100021, 2021.

    • IB-002 is effective in a clinically relevant mouse model of neuroblastoma.​

  • Cano-Mejia J, Shukla A, Ledezma DK, Palmer E, Villagra A, Fernandes R. "CpG-coated Prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma," Translational Oncology, Vol. 13, No. 10, 100823, 2020.

    • Mice with two tumors were completely cured when only one tumor was treated with IB-002.

  • Cano-Mejia J, Bookstaver ML, Sweeney EE, Jewell CM and Fernandes R. "Prussian blue nanoparticles-based antigenicity and adjuvanticity trigger robust antitumor immune responses against neuroblastoma," Biomaterials Science, Vol .7, 1875-1887, 2019.

    • IB-002 enables immune cell recognition and response in mice with neuroblastoma.

  • Sweeney EE*, Cano-Mejia J* and Fernandes R. "Photothermal therapy generates a thermal window of immunogenic cell death in neuroblastoma, " Small, Vol. 14, No. 20, 1800678, 2018.

    • Nanoparticle-based therapy can be tuned to stimulate an immune response in mice.

  • Cano-Mejia J, Burga RA, Sweeney EE, Fisher JP, Bollard CM, Sandler AD, Cruz CRY and Fernandes R. “Prussian blue nanoparticle-based photothermal therapy combined with checkpoint inhibition for photothermal immunotherapy of neuroblastoma,” Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 13, No. 2, 771-781, 2017.

    • IB-002 is effective in curing mice with neuroblastoma.

  • Sweeney EE, Burga RA, Li C, Zhu Y and Fernandes R. “Photothermal therapy improves the efficacy of a MEK inhibitor in neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors,” Scientific Reports, Vol. 6, No. 37035, 2016.

    • Nanoparticle-based therapy can alter typical cancer-associated signaling pathways.

  • Burga RA, Patel S, Bollard CM, Cruz CRY and Fernandes R. "Conjugating Prussian blue nanoparticles onto antigen-specific T cells as a combined nanoimmunotherapy," Nanomedicine, Vol. 11, No. 14,  1759-1767, 2016. ​

    • Our nanoparticles can be conjugated to immune cells for combination therapy.​

  • Hoffman HA, Chakrabarti L, Dumont MF, Sandler AD and Fernandes R. “Prussian blue nanoparticles for laser-induced photothermal therapy of tumors,” RSC Advances, Vol. 4, No. 56, 29729-29734, 2014.

    • Nanoparticle-based therapy can effectively treat mice with neuroblastoma.