Pre-clinical validation

Phase 1 trial

Phase 2 trial

Phase 3 trial

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IB-001

Nanoparticle-mediated immunotherapy for advanced melanoma

Pre-clinical validation

Phase 1 trial

Phase 2 trial

Phase 3 trial

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IB-002

Combination nano-immunotherapy for neuroblastoma

Awarded patents

  1. Fernandes R, Dumont MF, Sze RW, Conklin LS, Jaiswal JK, Hoffman HA. “Prussian-blue inspired constructs for multimodal imaging and therapy.” US Patent 9,561,183

  2. Fernandes R, Dumont MF, Sze RW, Conklin LS, Jaiswal JK, Hoffman HA. "Prussian blue-inspired constructs for multimodal imaging and therapy." US Patent 9,987,378.

Patents pending

  1. Fernandes R, Sze RW, Cruz CRY, Sandler AD, Bollard CM, Sweeney EE, Cano-Mejia J, Burga RA, Dumont MF. “Functionalized prussian blue nanoparticles, combination prussian blue nanoparticle-based nano-immunotherapy and applications thereof,” WO2017156148A1

  2. Fernandes R, Sweeney EE, Cano-Mejia J. “Prussian blue nanoparticles functionalized with immune signals and applications thereof,” Patent Application Number Pending.

  3. Fernandes R, Sweeney EE, Balakrishnan P, Cruz CRY, Sekhri P, Tovar M. "Nanoparticle-mediated immune cell manufacture and applications thereof," Patent Application Number Pending.

  4. Fernandes R, Sweeney EE, Balakrishnan P, Medina J. "Method for treating checkpoint inhibitor-resistant cancer using Prussian blue nanoparticle-based photothermal therapy combined with immune cell stimulating agonistic agents," Patent Application Number Pending.